MADONNA.  From the Italian word Madonna, meaning "My Lady." 
    Madonna, an American actress, recording artist and entrepreneur. (Wiki)

    In early days an Italian in addressing a lady used the word Madonna, which, like the French word Madame, means My Lady.  Now he says Signora; Madonna would have to him an old-fashioned sound.  To the rest of the world this word Madonna has come to be applied almost wholly to the Virgin Mary, with or without the child Jesus; and as Raphael painted a great many pictures of the Madonna for churches or other sacred places, a name has been given to each, drawn usually from some circumstance about it. (Raphael: a Collection of Fifteen Pictures and a Portrait of the Painter, Hurll, 1899).